{"id":1173,"date":"2026-10-01T20:18:16","date_gmt":"2026-10-01T18:18:16","guid":{"rendered":"https:\/\/upagainstcancer.org\/domino-effect\/"},"modified":"2026-10-08T17:05:05","modified_gmt":"2026-10-08T15:05:05","slug":"domino-effect","status":"publish","type":"page","link":"https:\/\/upagainstcancer.org\/nl\/onze-projecten\/domino-effect\/","title":{"rendered":"Domino-effect"},"content":{"rendered":"<style id=\"nectar-blocks-row-css\">.nectar-blocks-row.nectar-blocks-row__inner.nectar-blocks-row__wrapper{height:auto}.nectar-blocks-row.nectar-blocks-row__inner.nectar-blocks-row__wrapper:not(.alignfull){width:auto}.nectar-blocks-row.nectar-l1{align-items:stretch;box-sizing:border-box;display:flex;flex-direction:row;flex-wrap:nowrap;gap:var(--column-gap)}.nectar-blocks-row.nectar-l1:not(.alignfull){width:auto}@media only screen and (max-width:1024px)and (min-width:768px){.nectar-blocks-row.nectar-l1:not(.is-horizontal-tablet)>.nectar-blocks-column{flex:auto!important}}@media only screen 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nectar__bg-color\"><\/div><div class=\"nectar__bg-layer nectar__bg-image lazy-load-bg\"><\/div><\/div><div class=\"nectar-blocks-row__inner is-contained-content scope-block-ab86f3ef7f\"><style id=\"nectar-blocks-column-css\">.wp-block{opacity:1}.nectar-blocks-column{min-width:0;position:relative;transition:all .25s ease}.nectar-blocks-column>a{color:inherit}.nectar-blocks-column.nectar-blocks-column__content-wrap{height:auto}.nectar-blocks-column.nectar-l1{box-sizing:border-box;display:flex;flex-direction:column;width:100%}.nectar-blocks-column.nectar-l3>.nectar-blocks-column__wrapper>.nectar-blocks-column__inner{position:static}.nectar-blocks-column.nectar-l3>.nectar-blocks-column__wrapper:has(>.nectar__bg-layers>*){z-index:0}.nectar-blocks-column.nectar-l3>.nectar-blocks-column__wrapper:has(>.nectar__bg-layers>*)>.nectar__bg-layers{z-index:-1}.nectar-blocks-column 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ease}.nectar-blocks-flex-box__wrapper>.nectar__bg-layers{border-radius:inherit;transition:none}.nectar-blocks-flex-box__inner{box-sizing:border-box;height:100%;min-height:inherit;position:relative;transition:all .25s ease;width:100%}.nectar-blocks-flex-box__content-wrap{display:flex;flex-direction:column;height:100%;width:100%}.nectar-blocks-flex-box__link-overlay{background:#0000;color:inherit;display:block;inset:0;position:absolute;z-index:10}\n<\/style>\n<div class=\"wp-block-nectar-blocks-flex-box nectar-block nectar-blocks-flex-box nectar-l1\" id=\"block-28bbfbd451\"><style id=\"nectar-blocks-image-css\">.nectar-blocks-image{transition:all .25s ease}.nectar-blocks-image__inner{position:relative;transition:all .25s ease;width:100%}.nectar-blocks-image .nectar-blocks-image__inner{border-radius:inherit}.nectar-blocks-image img{border-radius:inherit;display:block;max-width:100%;transition:all .25s ease}.nectar-blocks-image img.nectar-aspect-ratio{object-fit:cover}\n<\/style>\n<div class=\"wp-block-nectar-blocks-image nectar-blocks-image\" id=\"block-bedbc063de\"><img loading=\"lazy\" decoding=\"async\" width=\"12\" height=\"12\" class=\"wp-image-136\" src=\"https:\/\/upagainstcancer.org\/wp-content\/uploads\/2026\/09\/Light-Blue-B4D1E2.svg\" alt=\"\" title=\"Light Blue #B4D1E2\"\/><\/div>\n\n\n<style id=\"nectar-blocks-text-css\">span.nectar-blocks-text{display:block}.nectar-blocks-text{background-size:cover;transition:background-color .25s ease,color .25s ease}.nectar-blocks-text *{text-indent:0}.nectar-blocks-text__inner{position:relative}.nectar-blocks-text__fit-text{display:inline-block;white-space:nowrap}.nectar-blocks-text.text-animation--reveal .line,.nectar-blocks-text.text-animation--reveal .word{clip-path:inset(0 -10px)}.nectar-blocks-text.text-animation--target-character .word{display:inline-block;white-space:nowrap}.nectar-blocks-text.doing-text-animation .nectar-blocks-text__highlight svg{opacity:0}.nectar-blocks-text.doing-text-animation .nectar-blocks-text__highlight--underline{background-image:none!important}.nectar-blocks-text.is-animated .line,.nectar-blocks-text.is-animated .word{clip-path:none}.nectar-blocks-text.has-fit-text,.nectar-blocks-text.has-fit-text *{letter-spacing:0}.nectar-blocks-text.has-fit-text{opacity:0}.nectar-blocks-text.has-fit-text--loaded{opacity:1}.nectar-blocks-text.has-fit-text br{display:none!important}.nectar-blocks-text.has-fit-text{line-height:.9}.nectar-blocks-text.has-fit-text [class*=text-animation--]{line-height:1.1}.nectar-blocks-text.has-fit-text{padding-left:0!important;padding-right:0!important}.nectar-blocks-text.has-text-highlight{z-index:1}.nectar-blocks-text.has-text-highlight .nectar-blocks-text__highlight{display:inline-block;line-height:1.1;position:relative}.nectar-blocks-text.has-text-highlight .nectar-blocks-text__highlight--underline{display:inline!important}.nectar-blocks-text.has-text-highlight .nectar-blocks-text__highlight svg{content:\"\";display:block;height:60%;left:0;pointer-events:none;position:absolute!important;top:70%;width:100%;z-index:-1}.nectar-blocks-text.has-text-highlight .nectar-blocks-text__highlight svg path{stroke-dasharray:1}.nectar-blocks-text.has-text-highlight.doing-text-animation:not(.has-fit-text) .nectar-blocks-text__highlight{line-height:inherit}@media only screen and (min-width:1025px){.nectar-blocks-text.text-animation--desktop.pre-animated{opacity:0!important}.nectar-blocks-text.text-animation--desktop.has-text-highlight-animation .nectar-blocks-text__highlight svg path{opacity:0;stroke-dashoffset:1}}@media only screen and (max-width:1024px)and (min-width:768px){.nectar-blocks-text.text-animation--tablet.pre-animated{opacity:0!important}.nectar-blocks-text.text-animation--tablet.has-text-highlight-animation .nectar-blocks-text__highlight svg path{opacity:0;stroke-dashoffset:1}}@media only screen and (max-width:767px){.nectar-blocks-text.text-animation--mobile.pre-animated{opacity:0!important}.nectar-blocks-text.text-animation--mobile.has-text-highlight-animation .nectar-blocks-text__highlight svg path{opacity:0;stroke-dashoffset:1}}@media(prefers-reduced-motion:reduce){.nectar-blocks-text{transition:none}.nectar-blocks-text.pre-animated{opacity:1!important}}\n<\/style>\n<h5 id=\"block-a72578589b\" class=\"wp-block-nectar-blocks-text nectar-blocks-text\">project<\/h5>\n<\/div>\n<\/div>\n\n\n\n<h1 id=\"block-631dd4f51e\" class=\"wp-block-nectar-blocks-text nectar-blocks-text\">Domino-effect<\/h1>\n\n\n\n<h2 id=\"block-3e9ca0ce54\" class=\"wp-block-nectar-blocks-text nectar-blocks-text nectar-gt-3dmEdFV6tc\">Immunotherapie tegen osteosarcoom (een zeer agressieve vorm van botkanker) en triple-negatieve borstkanker<\/h2>\n<\/div>\n<\/div><\/div><\/div>\n\n<div class=\"wp-block-nectar-blocks-row alignfull nectar-block nectar-blocks-row nectar-l2\" id=\"block-c56eee330c\"><div class=\"nectar-blocks-row__inner is-contained-content scope-block-c56eee330c\">\n<div class=\"wp-block-nectar-blocks-column nectar-blocks-column nectar-block nectar-l1\" id=\"block-2462a72cc4\">\n<div class=\"wp-block-nectar-blocks-flex-box nectar-block nectar-blocks-flex-box nectar-l1\" id=\"block-8f71788935\"><style id=\"nectar-blocks-button-css\">.wp-block{opacity:1}.nectar-blocks-button{display:flex;line-height:0;position:relative}.nectar-blocks-button .nectar-component__icon{line-height:0}.nectar-blocks-button .nectar-component__icon__img{height:1.2em;width:auto}.nectar-blocks-button .nectar-component__icon.icon-source--lucide svg path{fill:none}.nectar-blocks-button .nectar-component__icon svg{height:1.2em;width:auto}.nectar-blocks-button .nectar-component__icon svg path{fill:currentcolor}.nectar-blocks-button__icon{line-height:0}.nectar-blocks-button__icon svg{height:1em;width:auto}.nectar-blocks-button .nectar__bg-layers{border-radius:0;pointer-events:none}.nectar-blocks-button .nectar__link{align-items:center;color:inherit;display:flex;gap:.5em;justify-content:center;line-height:1;position:relative;text-decoration:none;transition:all .25s ease}.nectar-blocks-button>div.nectar-blocks-button__inner{transition:all .25s ease}@media(prefers-reduced-motion:reduce){.nectar-blocks-button .nectar-blocks-button__text,.nectar-blocks-button .nectar-blocks-button__text__inner,.nectar-blocks-button .nectar-blocks-button__text__inner:after,.nectar-blocks-button .nectar__link,.nectar-blocks-button>div.nectar-blocks-button__inner{transition:none!important}.nectar-blocks-button .hover .nectar-blocks-button__icon svg>g path,.nectar-blocks-button .hover .nectar-blocks-button__icon svg>path,.nectar-blocks-button .hover svg{animation:none!important}.nectar-blocks-button .hover .char{animation:none!important;opacity:1!important;transform:none!important}}\n<\/style>\n<div class=\"wp-block-nectar-blocks-button nectar-blocks-button nectar-gt-hVL9N2WADo\" id=\"block-e76ea65cc4\"><a href=\"#\" class=\"nectar__link nectar-blocks-button__inner\"><span class=\"nectar-blocks-button__text\">Melanoom (huidkanker)<\/span><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/upagainstcancer.org\/wp-content\/uploads\/2026\/09\/Blue-71AADD.svg\" alt=\"\" height=\"300\" width=\"300\" class=\"nectar-component__icon__img wp-image-133\"\/><\/a><\/div>\n\n\n\n<div class=\"wp-block-nectar-blocks-button nectar-blocks-button nectar-gt-hVL9N2WADo\" id=\"block-399e594c4b\"><a href=\"#\" class=\"nectar__link nectar-blocks-button__inner\"><span class=\"nectar-blocks-button__text\">darmkankers die resistent zijn tegen conventionele behandelingen.<\/span><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/upagainstcancer.org\/wp-content\/uploads\/2026\/09\/Blue-71AADD.svg\" alt=\"\" height=\"300\" width=\"300\" class=\"nectar-component__icon__img wp-image-133\"\/><\/a><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-nectar-blocks-flex-box nectar-block nectar-blocks-flex-box nectar-l1\" id=\"block-19cde54867\">\n<div class=\"wp-block-nectar-blocks-image nectar-blocks-image\" id=\"block-xZpwev5YOs\"><img loading=\"lazy\" decoding=\"async\" width=\"756\" height=\"82\" class=\"wp-image-759\" src=\"https:\/\/upagainstcancer.org\/wp-content\/uploads\/2026\/10\/THERAtrame.png\" alt=\"\" title=\"THERAtrame\" srcset=\"https:\/\/upagainstcancer.org\/wp-content\/uploads\/2026\/10\/THERAtrame.png 756w, https:\/\/upagainstcancer.org\/wp-content\/uploads\/2026\/10\/THERAtrame-300x33.png 300w\" sizes=\"auto, (max-width: 756px) 100vw, 756px\" \/><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-nectar-blocks-column nectar-blocks-column nectar-block nectar-l1\" id=\"block-84c74330ac\">\n<div class=\"wp-block-nectar-blocks-flex-box nectar-block nectar-blocks-flex-box nectar-l1\" id=\"block-668ad30818\">\n<div class=\"wp-block-nectar-blocks-flex-box nectar-block nectar-blocks-flex-box nectar-l1\" id=\"block-bef2a037c7\">\n<div class=\"wp-block-nectar-blocks-image nectar-blocks-image\" id=\"block-570400c0d0\"><img loading=\"lazy\" decoding=\"async\" width=\"12\" height=\"12\" class=\"wp-image-141\" src=\"https:\/\/upagainstcancer.org\/wp-content\/uploads\/2026\/09\/Off-White-F8F5F1.svg\" alt=\"\" title=\"Off White #F8F5F1\"\/><\/div>\n\n\n\n<h5 id=\"block-74bc3c7307\" class=\"wp-block-nectar-blocks-text nectar-blocks-text\">details<\/h5>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-nectar-blocks-column nectar-blocks-column nectar-block nectar-l1\" id=\"block-832e47d8b9\">\n<div class=\"wp-block-nectar-blocks-flex-box nectar-block nectar-blocks-flex-box nectar-l1\" id=\"block-415ed05618\">\n<div class=\"wp-block-nectar-blocks-flex-box nectar-block nectar-blocks-flex-box nectar-l1\" id=\"block-fc9f4c2a72\">\n<div class=\"wp-block-nectar-blocks-image nectar-blocks-image\" id=\"block-uY479nAI1b\"><img loading=\"lazy\" decoding=\"async\" width=\"500\" height=\"500\" class=\"wp-image-758\" src=\"https:\/\/upagainstcancer.org\/wp-content\/uploads\/2026\/10\/domino.jpg\" alt=\"\" title=\"domino\" srcset=\"https:\/\/upagainstcancer.org\/wp-content\/uploads\/2026\/10\/domino.jpg 500w, https:\/\/upagainstcancer.org\/wp-content\/uploads\/2026\/10\/domino-300x300.jpg 300w, https:\/\/upagainstcancer.org\/wp-content\/uploads\/2026\/10\/domino-150x150.jpg 150w, https:\/\/upagainstcancer.org\/wp-content\/uploads\/2026\/10\/domino-200x200.jpg 200w\" sizes=\"auto, (max-width: 500px) 100vw, 500px\" \/><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-nectar-blocks-flex-box nectar-block nectar-blocks-flex-box nectar-l1\" id=\"block-3a9d7b912e\">\n<div class=\"wp-block-nectar-blocks-flex-box nectar-block nectar-blocks-flex-box nectar-l1\" id=\"block-59e907886f\">\n<div class=\"wp-block-nectar-blocks-flex-box nectar-block nectar-blocks-flex-box nectar-l1\" id=\"block-DrQPAnOha3\">\n<div class=\"wp-block-nectar-blocks-flex-box nectar-block nectar-blocks-flex-box nectar-l1\" id=\"block-2519534de1\">\n<div class=\"wp-block-nectar-blocks-flex-box nectar-block nectar-blocks-flex-box nectar-l1\" id=\"block-73dda6655d\">\n<h6 id=\"block-bfe7fcb23c\" class=\"wp-block-nectar-blocks-text nectar-blocks-text nectar-font-h5\">betrokken pati\u00ebnten (nieuwe diagnoses per jaar)<\/h6>\n<\/div>\n\n\n\n<div class=\"wp-block-nectar-blocks-flex-box nectar-block nectar-blocks-flex-box nectar-l1\" id=\"block-aa76d75fa8\">\n<p id=\"block-VCaaBzleap\" class=\"wp-block-nectar-blocks-text nectar-blocks-text\">Melanomen: wereldwijd ~ 338 000 Europa (EU-27)  ~ 151 000<\/p>\n\n\n\n<p id=\"block-Ye3fX7o2ZT\" class=\"wp-block-nectar-blocks-text nectar-blocks-text\">Darmkanker: wereldwijd ~  2 000 000 Europa  ~ 527 000<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-nectar-blocks-flex-box nectar-block nectar-blocks-flex-box nectar-l1\" id=\"block-e7195968f7\">\n<div class=\"wp-block-nectar-blocks-flex-box nectar-block nectar-blocks-flex-box nectar-l1\" id=\"block-57e99e776c\">\n<h6 id=\"block-da1a190ebf\" class=\"wp-block-nectar-blocks-text nectar-blocks-text nectar-font-h5\">Type therapie<\/h6>\n<\/div>\n\n\n\n<div class=\"wp-block-nectar-blocks-flex-box nectar-block nectar-blocks-flex-box nectar-l1\" id=\"block-0e0b4e9dfc\">\n<p id=\"block-43999fc0a9\" class=\"wp-block-nectar-blocks-text nectar-blocks-text\">Immunotherapie<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-nectar-blocks-flex-box nectar-block nectar-blocks-flex-box nectar-l1\" id=\"block-5bf1ddeb78\">\n<div class=\"wp-block-nectar-blocks-flex-box nectar-block nectar-blocks-flex-box nectar-l1\" id=\"block-810cceb53a\">\n<h6 id=\"block-045514e80f\" class=\"wp-block-nectar-blocks-text nectar-blocks-text nectar-font-h5\">Reeds toegekende steun <\/h6>\n<\/div>\n\n\n\n<div class=\"wp-block-nectar-blocks-flex-box nectar-block nectar-blocks-flex-box nectar-l1\" id=\"block-56f320ce65\">\n<p id=\"block-7d376aaaa4\" class=\"wp-block-nectar-blocks-text nectar-blocks-text\">1.125.000 \u20ac<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-nectar-blocks-flex-box nectar-block nectar-blocks-flex-box nectar-l1\" id=\"block-5fd6779e53\">\n<div class=\"wp-block-nectar-blocks-flex-box nectar-block nectar-blocks-flex-box nectar-l1\" id=\"block-da6cf94897\">\n<h6 id=\"block-c08618a453\" class=\"wp-block-nectar-blocks-text nectar-blocks-text nectar-font-h5\">Start van het project<\/h6>\n<\/div>\n\n\n\n<div class=\"wp-block-nectar-blocks-flex-box nectar-block nectar-blocks-flex-box nectar-l1\" id=\"block-0973fa5f24\">\n<p id=\"block-27248138ad\" class=\"wp-block-nectar-blocks-text nectar-blocks-text\">2025<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-nectar-blocks-flex-box nectar-block nectar-blocks-flex-box nectar-l1\" id=\"block-76163e5bac\">\n<p id=\"block-1ae1cc6a01\" class=\"wp-block-nectar-blocks-text nectar-blocks-text\"><strong>Onze projectdragers ontwikkelen een behandeling die een enzym (ELP3) blokkeert dat cruciaal is voor de groei en de weerstand van kankercellen. De werking ervan zal een dubbel effect hebben: de zelfvernietiging van de tumorcellen \u00c9N de activering van ons immuunsysteem om ze uit te schakelen.<\/strong><\/p>\n\n\n\n<p id=\"block-duPAlE5NCY\" class=\"wp-block-nectar-blocks-text nectar-blocks-text\">Om snel te groeien en weerstand te bieden aan behandelingen, maken kankercellen massaal bepaalde eiwitten aan.<\/p>\n\n\n\n<p id=\"block-M55sDIQHIA\" class=\"wp-block-nectar-blocks-text nectar-blocks-text\">In het hart van deze dynamiek speelt een enzym (ELP3) een beslissende rol. Beeldend gezegd levert het de olie die de raderen van de tumormachine nodig hebben om op volle toeren te draaien en aanvallen te overleven.<\/p>\n\n\n\n<p id=\"block-c7ea7c2910\" class=\"wp-block-nectar-blocks-text nectar-blocks-text\">Opmerkelijk is dat de kankerstamcellen die aan de basis van hervallen liggen bijzonder afhankelijk zijn van deze ELP3-enzymen om van vorm te veranderen, zich te verplaatsen, aan het immuunsysteem te ontsnappen en weerstand te bieden aan behandelingen.<\/p>\n\n\n\n<p id=\"block-1aa1f58d2a\" class=\"wp-block-nectar-blocks-text nectar-blocks-text\">Dit project wil een innovatieve molecule ontwikkelen <strong><\/strong>die het enzym ELP3 blokkeert en <strong>een dubbel effect<\/strong> teweegbrengt: de zelfvernietiging van de tumorcellen \u00c9N de activering van het immuunsysteem om ze uit te schakelen.<\/p>\n\n\n\n<div class=\"wp-block-nectar-blocks-flex-box nectar-block nectar-blocks-flex-box nectar-l1\" id=\"block-81876cfaf3\">\n<div class=\"wp-block-nectar-blocks-button nectar-blocks-button nectar-gt-hVL9N2WADo\" id=\"block-c4851962e2\"><a href=\"https:\/\/donate.kbs-frb.be\/FADlaFondationFournierMajoie\/~mon-don\" target=\"_blank\" rel=\"noreferrer noopener\" class=\"nectar__link nectar-blocks-button__inner\"><span class=\"nectar-blocks-button__text\">Steun dit project<\/span><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/upagainstcancer.org\/wp-content\/uploads\/2026\/09\/Blue-71AADD.svg\" alt=\"\" height=\"300\" width=\"300\" class=\"nectar-component__icon__img wp-image-133\"\/><\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n<div class=\"wp-block-nectar-blocks-row alignfull nectar-block nectar-blocks-row nectar-l2\" id=\"block-c1ebbb42f0\"><div class=\"nectar-blocks-row__inner is-contained-content scope-block-c1ebbb42f0\">\n<div class=\"wp-block-nectar-blocks-column nectar-blocks-column nectar-block nectar-l1\" id=\"block-6d476e454a\">\n<div class=\"wp-block-nectar-blocks-flex-box nectar-block nectar-blocks-flex-box nectar-l1\" id=\"block-967322273e\">\n<h2 id=\"block-01a8a9f603\" class=\"wp-block-nectar-blocks-text nectar-blocks-text\">Domino-effect 1<\/h2>\n<\/div>\n<\/div>\n\n\r\n\n<div class=\"wp-block-nectar-blocks-column nectar-blocks-column nectar-block nectar-l1\" id=\"block-ae36426e8e\">\n<p id=\"block-189f77c400\" class=\"wp-block-nectar-blocks-text nectar-blocks-text nectar-gt-3dmEdFV6tc\">De molecule die onze projectdraagster ontwikkelt, werkt door dit enzym te blokkeren.<\/p>\n\n\n\n<p id=\"block-5e3f197591\" class=\"wp-block-nectar-blocks-text nectar-blocks-text\">Dat verstoort de aanmaak van de groei- en weerstandseiwitten zodanig dat de verzwakte kankercellen zichzelf vernietigen.<\/p>\n<\/div>\n<\/div><\/div>\n\n<div class=\"wp-block-nectar-blocks-row alignfull nectar-block nectar-blocks-row nectar-l2\" id=\"block-e166729b97\"><div class=\"nectar-blocks-row__inner is-contained-content scope-block-e166729b97\">\n<div class=\"wp-block-nectar-blocks-column nectar-blocks-column nectar-block nectar-l1\" id=\"block-64fdce513d\">\n<div class=\"wp-block-nectar-blocks-flex-box nectar-block nectar-blocks-flex-box nectar-l1\" id=\"block-543ffb4cf3\">\n<h2 id=\"block-f87b7666fe\" class=\"wp-block-nectar-blocks-text nectar-blocks-text\">Domino-effect 2<\/h2>\n<\/div>\n<\/div>\n\n\r\n\n<div class=\"wp-block-nectar-blocks-column nectar-blocks-column nectar-block nectar-l1\" id=\"block-bea7925d5d\">\n<p id=\"block-0fac353980\" class=\"wp-block-nectar-blocks-text nectar-blocks-text\">De veroorzaakte blokkades dwingen de kankercellen om signalen aan hun oppervlak uit te zenden. Die trekken verschillende &#8220;soldaten&#8221; van ons immuunsysteem aan (T-lymfocyten, maar ook NK-cellen), die ze aanvallen en uitschakelen.<\/p>\n\n\n\n<p id=\"block-18e35a8c7d\" class=\"wp-block-nectar-blocks-text nectar-blocks-text\">In een eerste fase wordt de molecule ontwikkeld tegen melanomen (stadium III en IV) om de optimale en verdraagbare dosis van de behandeling te bepalen.<br\/>Daarna zal ze zich richten op darmkankers, waarvan het hervalpercentage zeer hoog is (30 tot 40% binnen 3 jaar).<\/p>\n<\/div>\n<\/div><\/div>\n\n<div class=\"wp-block-nectar-blocks-row alignfull nectar-block nectar-blocks-row nectar-l2\" id=\"block-fef4541380\"><div class=\"nectar-blocks-row__inner is-contained-content scope-block-fef4541380\">\n<div class=\"wp-block-nectar-blocks-column nectar-blocks-column nectar-block nectar-l1\" id=\"block-0f40d08ebf\">\n<h2 id=\"block-aeb5ba0f23\" class=\"wp-block-nectar-blocks-text nectar-blocks-text has-text-highlight has-text-highlight-animation text-animation--desktop text-animation--tablet text-animation--mobile\" data-text-animation=\"{&quot;highlightAnimation&quot;:true,&quot;textAnimationEffect&quot;:&quot;none&quot;,&quot;timeBetween&quot;:0.02,&quot;easing&quot;:[0.65,0,0.35,1],&quot;duration&quot;:1.2,&quot;delay&quot;:0,&quot;deviceTrigger&quot;:[&quot;desktop&quot;,&quot;tablet&quot;,&quot;mobile&quot;]}\" data-nectar-block-animation=\"{&quot;selector&quot;:&quot;self&quot;,&quot;scrollIntoView&quot;:{&quot;type&quot;:&quot;scrollIntoView&quot;,&quot;triggerDevices&quot;:[&quot;desktop&quot;,&quot;tablet&quot;,&quot;mobile&quot;],&quot;animation&quot;:{&quot;type&quot;:&quot;slide&quot;,&quot;playDirection&quot;:&quot;in&quot;,&quot;fromDirection&quot;:&quot;down&quot;},&quot;animationDurationSec&quot;:1,&quot;animationDelaySec&quot;:0,&quot;animationTimingFunction&quot;:[0.65,0,0.35,1]}}\" data-await-in-view-desktop=\"\" data-await-in-view-tablet=\"\" data-await-in-view-mobile=\"\">Op dit moment boeken nog andere veelbelovende pistes vooruitgang. Ontdek alle projecten die we steunen.<\/h2>\n\n\n\n<div class=\"wp-block-nectar-blocks-button nectar-blocks-button nectar-gt-hVL9N2WADo\" id=\"block-400fad050d\"><a href=\"https:\/\/upagainstcancer.org\/nl\/onze-projecten\/\" class=\"nectar__link nectar-blocks-button__inner\"><span class=\"nectar-blocks-button__text\">Alle projecten<\/span><img loading=\"lazy\" decoding=\"async\" width=\"32\" height=\"32\" src=\"https:\/\/upagainstcancer.org\/wp-content\/uploads\/2026\/09\/btn-picto-navy.png\" alt=\"\" class=\"nectar-component__icon__img wp-image-50\"\/><\/a><\/div>\n<\/div>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":1424,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_nectar_blocks_hide_post_title":false,"_nectar_blocks_transparent_header_effect":false,"_nectar_blocks_transparent_header_effect_color":"light","_nectar_blocks_header_animation":false,"_nectar_blocks_header_animation_delay":0,"_nectar_blocks_header_animation_effect":"fade","_nectar_blocks_page_css":"","_nectar_blocks_page_js":"","inline_featured_image":false,"footnotes":""},"class_list":["post-1173","page","type-page","status-publish"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Domino-effect - Up Against Cancer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/upagainstcancer.org\/nl\/onze-projecten\/domino-effect\/\" \/>\n<meta property=\"og:locale\" content=\"nl_NL\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Domino-effect - Up Against Cancer\" \/>\n<meta property=\"og:url\" content=\"https:\/\/upagainstcancer.org\/nl\/onze-projecten\/domino-effect\/\" \/>\n<meta property=\"og:site_name\" content=\"Up Against Cancer\" \/>\n<meta property=\"article:modified_time\" content=\"2026-10-08T15:05:05+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Geschatte leestijd\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minuut\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/upagainstcancer.org\\\/nl\\\/onze-projecten\\\/domino-effect\\\/\",\"url\":\"https:\\\/\\\/upagainstcancer.org\\\/nl\\\/onze-projecten\\\/domino-effect\\\/\",\"name\":\"Domino-effect - Up Against Cancer\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/upagainstcancer.org\\\/nl\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/upagainstcancer.org\\\/nl\\\/onze-projecten\\\/domino-effect\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/upagainstcancer.org\\\/nl\\\/onze-projecten\\\/domino-effect\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/upagainstcancer.org\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/Light-Blue-B4D1E2.svg\",\"datePublished\":\"2026-10-01T18:18:16+00:00\",\"dateModified\":\"2026-10-08T15:05:05+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/upagainstcancer.org\\\/nl\\\/onze-projecten\\\/domino-effect\\\/#breadcrumb\"},\"inLanguage\":\"nl-NL\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/upagainstcancer.org\\\/nl\\\/onze-projecten\\\/domino-effect\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"nl-NL\",\"@id\":\"https:\\\/\\\/upagainstcancer.org\\\/nl\\\/onze-projecten\\\/domino-effect\\\/#primaryimage\",\"url\":\"https:\\\/\\\/upagainstcancer.org\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/Light-Blue-B4D1E2.svg\",\"contentUrl\":\"https:\\\/\\\/upagainstcancer.org\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/Light-Blue-B4D1E2.svg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/upagainstcancer.org\\\/nl\\\/onze-projecten\\\/domino-effect\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\\\/\\\/upagainstcancer.org\\\/nl\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Onze projecten\",\"item\":\"https:\\\/\\\/upagainstcancer.org\\\/nl\\\/onze-projecten\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Domino-effect\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/upagainstcancer.org\\\/nl\\\/#website\",\"url\":\"https:\\\/\\\/upagainstcancer.org\\\/nl\\\/\",\"name\":\"Up Against Cancer\",\"description\":\"UP Against Cancer aide les chercheurs \u00e0 transformer leurs d\u00e9couvertes en traitements qui sauvent des vies. 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